Full-Time Bioinformatician for the Department of Human Genetics in the University of Chicago
SUMMARY: This highly innovative and cutting-edge NIH-funded multi-university National Center of Excellence (P50) from the National Institute of Drug Abuse is focused on genome wide association studies (GWAS) of behavioral traits in a complex outbred rat population. The candidate will analyze reduced representation next-generation sequencing data to call genotypes in approximately 5000 samples using an established pipeline. Imputation of missing data and of founder haplotypes will be performed using standard and customized tools. Genotype data will be used in conjunction with mixed linear models to identify genotype /phenotype associations. In addition RNA sequencing will be used to quantify gene expression which will be evaluated for association with genetic markers in an effort to identify expression QTLs. Most of these procedures have already been established in the lab but may require periodic modification and optimization. Data visualization tools will be implemented in a collaborative web-based environment. The successful candidate will interact via email, phone, web conference and in person with a dynamic team of junior and senior level researchers at the University of Chicago in the Departments of Human Genetics, Statistics, Genetic Medicine and Psychiatry as well as researchers at 4 other participating institutions.
JOB DESCRIPTION: Collaborates with researchers in designing, implementing, and publishing results from research projects and assumes primary responsibility for writing statistical design, methods, and analysis for research proposals. Collaborates with researchers and assists in developing objectives, designing sampling, randomization, and data collection procedures to achieve study objectives. Analyzes data and prepares tables for interim and final reports. Designs tables and statistical procedures for specific research studies. Develops the statistical design and planned analyses for research grant proposals and takes primary responsibility for writing the statistical design, including sample size, and statistical considerations in grant proposals for faculty throughout the unit. Assumes major responsibilities in research projects, e.g. serving on committees, supervising project personnel, coordinating quality control efforts, and serving on writing teams. Develops and implements new innovative procedures in the areas of data collection, quality control, presentation of results, and statistical analyses. Writes the results section of reports and publications. Writes statistical computer programs and reviews computer output for consistency and quality. May oversee the work of lower-level statisticians or data archivists.
EDUCATION: MA/MS or PhD in bioinformatics, biostatistics, computer science, machine learning, statistical genetics, or relevant quantitative field required.
EXPERIENCE: At least 2 years of programming experience using languages such as C, C++, Java, Python, R or similar is required. At least 2 years of experience with next-generation sequencing, genetics/genome wide association studies, genotype and haplotype imputation and gene expression data required.
COMPETENCIES: Strong communication skills and the ability to communicate with researchers with a variety of different expertise are required.
Ability to train others required.
Ability to coordinate the work of others required.
Advanced knowledge of statistics required.
Advanced knowledge of statistical software packages required.
Ability to write statistical computer programs required.
Knowledge of database management software required.
Analytical skills required.
Advanced computational skills required.
Problem-solving skills required.
Attention to detail required.
Organizational skills required.
Verbal and written communication skills required.
Ability to work independently and as part of a team required.
For more more details, please visit: https://jobopportunities.uchicago.edu/applicants/jsp/shared/position/JobDetails_css.jsp?postingId=623837.