- Edward Lee
I am a computational biologist who uses mathematical modeling and computational approaches to answer questions in the field of immunology. I am currently using R to:
(1) create a package containing a novel series of algorithms to process next-generation sequencing data of T cell receptors
(2) automate and process the gating of high dimensional flow cytometry data using machine-learning techniques
(3) implement ODE and PDE models of T cell dynamics
Ph.D. Candidate in Immunology, 2014-Present
University of Glasgow, Glasgow, UK
Advisor: Andrew J. Yates
M.D. Candidate, 2012-Present
Albert Einstein College of Medicine, Bronx, NY
B.A. in Mathematics and Biology, 2008-2012
The College of New Jersey, Ewing, NJ
Graduation with Highest Honors
Memorial Sloan-Kettering Cancer Center
May 2012 – August 2012, New York, NY
Developed a model that describes how T regulatory cells localize IL-2 signaling in a population of helper T cells by describing the dynamics of the diffusion of IL-2, signal transduction along the cell membrane, and the dynamics of the IL-2 receptor. The model and numerical scheme was programmed in C.
Piscataway, NJ, May 2011-December 2012
Advisor: Nina Fefferman
Provided programming and computational consultancy for members of the Fefferman lab. Projects included a linear programming model for bee population dynamics and a mathematical describing how HIV infection affects the emergence of new strains of other diseases in individual hosts and in populations.
The College of New Jersey
September 2010-May 2012, Ewing, NJ
Advisor: Leona A. Harris
Developed a physiologically-based pharmacokinetic (PBPK) model for the exposure to perfluorooctane sulfonate in pregnant rats and their fetuses, which included modeling the physiology of the pregnant rat and the developing fetuses.
Summer Research Student
North Carolina State University
June 2010-August 2010, Raleigh, NC
Advisor: Marina V. Evans
Lead a team of four students to develop a PBPK model for the coexposure of tricholorethylene and carbon tetrachloride in rats to test mechanistic hypotheses for the enzyme CYP2E1. Derived a novel kinetic equation to model the possibility of two separate active sites in CYP2E1 and the kinetic interactions between the two sites.
- R (4 years)
- MATLAB (7 years)
- C (2 years)
- C++ (1 year)
- Public speaking